Organ-Specific Clinicopathological Features That Are Associated With Post-Relapse Survival of Metastatic Breast Cancer in Japanese Women: A Multicenter Cohort Study.

ABSTRACT:

Background

Metastatic breast cancer (MBC) presents heterogeneous clinical behavior depending on the metastatic site and molecular subtype. However, only a few studies have directly compared prognostic outcomes by the organ of initial distant recurrence. This multi-institutional retrospective study aimed to clarify the clinical and biological characteristics of MBC based on cases with single-organ metastasis at the time of initial MBC diagnosis, using real-world data from Japanese patients.

Methods

We retrospectively analyzed 309 Japanese women treated for early-stage breast cancer at six institutions between 2007 and 2021, who developed distant recurrence confined to a single organ (brain, lungs, liver, or bones) as the first site of metastasis. Patients with multi-organ met

SUBMITTER: Koyama Y 

PROVIDER: S-EPMC12758093 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature