The relation of colchicine to total joint arthroplasty among people with gout in a population-based cohort study.

ABSTRACT:

Objectives

To evaluate the relation of colchicine use to the risk of total joint arthroplasty (TJA) in individuals with gout, the most common form of arthritis for which colchicine is prescribed.

Methods

This new-user design, time-stratified, population-based cohort study utilized a UK primary care database (2000 to 2021). We identified participants with gout who were newly prescribed colchicine after their gout diagnosis. Each colchicine initiator was propensity score-matched with a non-initiator using one-year cohort accrual blocks. The effect of colchicine on the risk of TJA was assessed using Cox proportional hazard regression. Analyses were repeated limited to participants with both gout and knee/hip osteoarthritis (OA).

Results

We identified 31,478 colchicine in

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12758127 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature