Systematic review of cardiac ventricular dysfunction in Wilson's disease: mechanisms, diagnostic advancements, and management strategies.

ABSTRACT:

Introduction

Wilson's disease (WD) is a rare autosomal recessive disorder caused by ATP7B gene mutations, leading to systemic copper accumulation. This systematic review examines the cardiac manifestations of WD and aims to summarize key diagnostic and therapeutic findings from available studies.

Methods

We conducted a systematic review of 21 studies using databases such as PubMed and Scopus. Studies were selected based on relevance to WD and cardiac involvement. Data extraction focused on diagnostic methods, outcomes, and treatments. Risk of bias and methodological quality were assessed qualitatively.

Results

A total of 21 studies were included. Cardiac complications included arrhythmias, myocardial fibrosis, and diastolic dysfunction. Oxidative stress and mitochondr

SUBMITTER: Hullon D 

PROVIDER: S-EPMC12758202 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature