Safety and efficacy of novel potassium binders for chronic hyperkalemia: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

Hyperkalemia is a potentially life-threatening electrolyte imbalance that contributes to increased morbidity and mortality in patients with heart failure (HF) and chronic kidney disease (CKD). Novel potassium binders (NPBs) have been shown to prevent hyperkalemia; however, their efficacy and safety have not been fully established.

Methods

We searched various electronic databases, including MEDLINE (via PubMed), Embase, the Cochrane Library, and ClinicalTrials.gov, to retrieve randomized controlled trials comparing NPB to placebo in patients with chronic hyperkalemia due to HF or CKD.

Results

Our meta-analysis, including 12 studies involving 2517 patients, showed that NPBs, including patiromer and sodium zirconium cyclosilicate, were associated with significa

SUBMITTER: Riaz AA 

PROVIDER: S-EPMC12758214 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature