Safety and efficacy of endoscopic submucosal dissection vs endoscopic mucosal resection in managing gastrointestinal tract tumors: a systematic review and meta-analysis.

ABSTRACT:

Background

Endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are minimally invasive alternatives to surgery for gastrointestinal tumors, differing in technique, indications, and outcomes. This meta-analysis compared the efficacy and safety of ESD vs EMR.

Methods

Following PRISMA guidelines, PubMed, Cochrane, Google Scholar, and Scopus were searched. Binary outcomes were pooled as odds ratios (ORs) and continuous outcomes as standardized mean differences (SMDs), with 95% confidence intervals (CIs), using a random-effects model. Analyses were performed in R (v4.4.1), with significance set at P < 0.05.

Results

Twenty-five studies with 5283 patients (2234 ESD, 3049 EMR) were included. ESD achieved higher complete resection (OR, 5.77; 95%

SUBMITTER: Bhat A 

PROVIDER: S-EPMC12758251 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature