Plasma expression of lncRNA Wisper in patients with heart failure and patients with myocardial infarction.

ABSTRACT:

Background

Heart failure (HF) and ST-elevation myocardial infarction (STEMI) are the major causes of morbidity and mortality worldwide. Recent evidence indicates that long noncoding RNAs (lncRNAs) participate in cardiac fibrosis, which develops to varying degrees in these conditions.

Patients and methods

This retrospective study analyzed the plasma expression levels of lncRNA Wisper using RT-qPCR in 28 patients with HF (NYHA class III - IV, reduced ejection fraction), 37 patients with STEMI, and 15 healthy controls. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curve analysis, and correlations with clinical parameters were evaluated.

Results and conclusions

Patients with HF and STEMI showed significantly higher plasma Wisper expression

SUBMITTER: Doneva JG 

PROVIDER: S-EPMC12758281 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature