Development of a novel diagnostic model integrating microRNAs and GALAD for HBV-related hepatocellular carcinoma.

ABSTRACT:

Aims

As primary hepatocellular carcinoma (HCC) is a prevalent digestive tract malignancy, identifying novel biomarkers for early diagnosis and prognosis is crucial. This study combined specific miRNAs with the GALAD model to create a new diagnostic model for hepatitis B virus (HBV)-related HCC.

Patients & methods

From 2020 to 2022, 884 patients from Zhongshan Hospital were enrolled, including 430 HBV-related HCC, 275 HBV-related chronic liver disease (CLD), and 179 healthy donors (HD). Stepwise regression selected features, and multivariable logistic regression built the GALADM model. A nomogram integrating age, gender, serum markers, and a score derived from seven plasma cell-free microRNAs (miRNA7) was developed.

Results

MiRNA7 value was higher in HCC patients and r

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12758346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature