Gut microbiome-derived propionate reprograms alveolar macrophages metabolically and regulates lung injury responses in mice.

ABSTRACT: Responses to lung injury can vary between individuals with the diet and gut microbiome representing two underappreciated sources for this variability. The gut microbiome can influence lung injury outcomes through the gut‒lung axis, but exactly how diet and its effects on the microbiota are involved remains unclear. We hypothesized that dietary fiber interventions would favor the presence of short-chain fatty acid (SCFA)-producing fermentative bacteria presence in the gut microbiome, thereby influencing the resting lung immunometabolic tone as well as influencing downstream responses to lung injury and infection. To test this hypothesis, we fed mice fiber-rich (FR) and fiber-free (FF) diets, and observed changes in the steady-state transcriptional programming of alveolar macrophages (AM). N

SUBMITTER: Maruyama D 

PROVIDER: S-EPMC12758369 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature