Prevalence of multidrug-resistant organisms colonizing neonates at a tertiary hospital in Johannesburg, South Africa.

ABSTRACT: Neonatal mortality remains a global health challenge, particularly in sub-Saharan Africa, where infections often caused by multidrug-resistant (MDR) organisms are a leading cause of death. This study aimed to assess the prevalence of MDR ESKAPE pathogens and Candida auris colonization among hospitalized neonates in a non-outbreak setting, identify associated risk factors, and characterize antimicrobial resistance patterns. A cross-sectional sub-study was conducted at a tertiary hospital in South Africa between November and December 2020. A total of 258 rectal and skin swabs were collected from 86 neonates and cultured for ESKAPE organisms and C. auris. Isolated MDR organisms underwent further characterization. Of the 135 ESKAPE + C. auris isolates identified, 70.4% (95/135) were MDR. Colon

SUBMITTER: Mntla N 

PROVIDER: S-EPMC12758378 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature