Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of <i>Drosophila</i> testis tumor stem cell-like cells.

ABSTRACT: Stem cells have the unique ability to self-renew and differentiate into specialized cell types. Epigenetic mechanisms, including histones and their post-translational modifications, play a crucial role in regulating programs integral to a cell's identity, like gene expression and DNA replication. However, the transcriptional, chromatin, and replication timing profiles of adult stem cells in vivo remain poorly understood. Containing germline stem cells (GSCs) and somatic cyst stem cells (CySCs), the Drosophila testis provides an excellent in vivo model for studying adult stem cells. However, the small number of stem cells and the cellular heterogeneity of this tissue have limited comprehensive genomic studies. In this study, we develop cell-type-specific genomic techniques to analyze

SUBMITTER: Urban JA 

PROVIDER: S-EPMC12758400 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature