Persistent Inflammation After Anti-Tubercular Therapy in Tubercular Serpiginous-Like Choroiditis: A Multivariate and Network-Based Risk Analysis.

ABSTRACT:

Purpose

Antitubercular therapy (ATT) for tubercular serpiginous-like choroiditis (TB-SLC) is well-established, but not infallible. In this study, we investigated the risk factors underlying persistent inflammation after ATT in TB-SLC patients.

Methods

We retrospectively reviewed consecutive TB-SLC patients, who completed ≥6 months of ATT. The primary outcome measure was persistent inflammation at the completion of ATT. The risk factors for persistent inflammation were analyzed using multivariate logistic regression. Additionally, a categorical network analysis was performed to explore the relationships among key clinical variables. The anti-inflammatory therapy was quantified as total immunosuppressive load (TIL) by scoring systemic and local corticosteroid treatments.

Re

SUBMITTER: Kesav N 

PROVIDER: S-EPMC12758418 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature