The Association of Polygenic Risk Score With Glaucoma and Its Related Traits: Results From Two German Population-Based Studies.

ABSTRACT:

Purpose

Genome-wide association studies have revealed many loci linked to glaucoma. The aim of this study was to explore the associations between a glaucoma polygenic risk score (GPRS) with glaucoma prevalence, intraocular pressure (IOP), and peripapillary retinal nerve fibre layer thickness (pRNFL) on a population-based level.

Methods

Participants of the Gutenberg Health Study (aged 40-80 years) and the AugUR Study (aged 70-95 years), two German population-based studies, were included. Of participants with genetic assessment 12,147 had glaucoma grading, 8938 data on IOP, and 7844 data on pRNFL. Spectral-domain optical coherence tomography was used to measure pRNFL thickness and noncontact tonometry for IOP measurements. Glaucoma was graded according to the classification of

SUBMITTER: Welzel AM 

PROVIDER: S-EPMC12758419 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature