Transcriptomic Profiling of Orbital Fat Tissue and Ocular Surface Wash in Active Thyroid Eye Disease Requiring Urgent Orbital Decompression.

ABSTRACT:

Purpose

Thyroid eye disease (TED) is an autoimmune disorder characterized by orbital inflammation and tissue remodeling. Although most patients with active TED respond to medical therapy, a subset develops sight-threatening complications which require urgent orbital decompression when conservative treatment fails. This study aimed to elucidate the molecular mechanisms underlying active, moderate-to-severe TED in patients requiring urgent orbital decompression during the active disease stage.

Methods

Transcriptomic profiling was performed on retro-orbital fat samples from 13 patients and ocular surface wash samples from 9 patients undergoing urgent orbital decompression, as well as on samples from control subjects. Differential gene expression, pathway enrichment, cell-type c

SUBMITTER: Petrackova A 

PROVIDER: S-EPMC12758420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature