Use of a Medication Management Algorithm in Depressed Youth Living with HIV: Secondary Analysis of a Multisite Randomized Controlled Trial.

ABSTRACT: Objectives: Depression is a prevalent co-occurring condition in youth living with HIV. This report is a secondary analysis of a multisite cluster randomized trial evaluating the efficacy of a health and wellness cognitive behavioral therapy (CBT) combined with a medication management algorithm utilizing measure-based care (COMB-R) compared with enhanced standard of care (ESC). We describe and compare antidepressant prescribing strategies (i.e., antidepressant treatment, type of antidepressant) for youth living with HIV at COMB-R sites to those at ESC sites over the 24-week intervention. We also describe self-reported adherence to antidepressants. Methods: Participants (12-24 years) were youth living with HIV diagnosed with moderate to severe depression (Quick In

SUBMITTER: Emslie GJ 

PROVIDER: S-EPMC12758447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature