Association of maternal metabolic conditions with mitochondrial DNA copy number in cord blood.

ABSTRACT:

Background

Mitochondrial dysfunction has been linked with metabolic disorders, given the central role of mitochondria in multiple crucial metabolic processes. However, little is known about how maternal metabolic conditions may affect mitochondrial function in newborns, although several other prenatal exposures have been associated with impaired mitochondrial function in either the placenta or cord blood. This study aimed to assess the association between maternal metabolic conditions and mitochondrial DNA copy number (mtDNA-CN, as a biomarker for mitochondrial function) in newborns.

Methods

Among 999 mother-newborn pairs from the Boston Birth Cohort, mtDNA-CN in newborn umbilical cord blood and maternal blood collected at delivery were measured by a targeted genome sequenci

SUBMITTER: Qu X 

PROVIDER: S-EPMC12758450 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature