Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model.

ABSTRACT: The International Space Station provides an opportunity to study the impact of spaceflight on gene expression and possible links to human health. Our study investigates global changes in messenger RNA (mRNA) abundance in the THP-1 cell line, a monocyte-macrophage lineage known for plasticity and immune reprogramming features. We identified pathways positively enriched with genes affecting muscle and cardiac contraction, neuronal system, and sensory perception. Available computational models identified links with health issues, including cardiac, neurological, muscular, and renal disorders and alterations in senses. Specific mechanistic networks were identified: retinoid metabolism, cAMP (adenosine 3',5'-monophosphate)/CREB (cAMP response element-binding protein) signaling, and glutamatergi

SUBMITTER: Al-Ahmadi W 

PROVIDER: S-EPMC12758520 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature