Partially Successful Adrenal Vein Sampling With and Without Cross-Sectional Imaging in Primary Aldosteronism Subtyping.

ABSTRACT:

Background

Adrenal vein (AV) sampling (AVS) is used to guide therapy in primary aldosteronism (PA). When a single AV is successfully cannulated, the relative aldosterone secretion index (RASI), which compares the aldosterone/cortisol ratio in that AV versus the periphery, has been proposed as sufficient for PA subtyping, particularly when <1. Data on RASI reliability have, however, been inconsistent.

Methods

This retrospective cohort study included patients with PA who underwent AVS before and after cosyntropin stimulation at a referral center between January 2015 and December 2024. To simulate partially successful AVS, RASI was calculated from patients with successful bilateral AV cannulation and compared across PA subtypes and postoperative outcomes, with assessment of dis

SUBMITTER: Vibhatavata P 

PROVIDER: S-EPMC12758631 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature