GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family.

ABSTRACT: Tristetraprolin or TTP is an RNA-binding protein that possesses two CCCH-like zinc-finger domains that bind AU-rich elements to promote their degradation. One of its targets is the mRNA of tumor necrosis factor alpha (TNF-α). When TTP is absent, the TNF-α factor accumulates causing severe, generalized inflammation in knockout mice. TTP is also considered a tumor suppressor protein because it regulates the expression of several mRNAs that encode for proteins involved in cell cycle regulation and it is downregulated in various types of human cancers. Under stress, TTP associates with stress granules (SGs), dynamic cytoplasmic condensates formed by liquid-liquid phase separation (LLPS) that protect mRNAs from harmful conditions. Despite TTP's important role in mRNA turnover, much remains to b

SUBMITTER: Salinas LS 

PROVIDER: S-EPMC12758685 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature