Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.

ABSTRACT: Bipolar affective disorder (BPAD) is a chronic psychiatric condition with high heritability (60-85%) and significant phenotypic variability, complicating its etiological understanding. Genome-wide association studies (GWAS) have revealed genetic overlaps with diverse traits, suggesting pleiotropy. This study aimed to identify shared genetic factors and infer causal relationships using large-scale GWAS data.BPAD GWAS summary statistics were obtained from the UK Biobank via the Complex Trait Genetics Virtual Lab (CTG-VL) platform. Genetic correlations with 1,504 traits were estimated using linkage disequilibrium score regression (LDSC), with quality filters ensuring heritability (h² > 0.05, p < 0.05). The latent causal variable (LCV) model was applied to assess genetic causal proportion (GCP

SUBMITTER: Hu B 

PROVIDER: S-EPMC12758722 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature