Markers of clinical and mitochondrial adaptation in response to moderate intensity continuous training: A systematic review and meta-analysis.

ABSTRACT:

Background

Aerobic exercise promotes mitochondrial morphological, enzymatic, and bioenergetic adaptions to improve muscle health and function. Although moderate intensity continuous training (MICT) is frequently recommended for sedentary and multiple clinical populations, there is little consensus regarding the effects of chronic MICT on these adaptations. The aim of this systematic review and meta-analysis is to evaluate the evidence for the effects of MICT on molecular transducers of mitochondrial biogenesis and cardiorespiratory fitness in adults.

Methods

A comprehensive search was conducted in PubMed and CINAHL. Eligible studies assessed MICT lasting ≥2 weeks in adults, published since 2010, and collected vastus lateralis skeletal muscle biopsies pre and post chronic end

SUBMITTER: Vabishchevich V 

PROVIDER: S-EPMC12758752 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature