Prognostic value of red blood cell distribution width in traumatic brain injury: A mediation and deep learning analysis.

ABSTRACT: This study aimed to investigate the associations between age, red blood cell distribution width (RDW), and short-term mortality in patients with traumatic brain injury (TBI), with a particular focus on the role of RDW in mediating the impact of age on mortality. We conducted a retrospective cohort analysis of 1,203 ICU-admitted TBI patients from the MIMIC-IV database (v3.1). Cox proportional hazards regression, restricted cubic splines (RCS), and mediation analysis were employed to evaluate the relationships between age, RDW, and mortality outcomes. Both advanced age (adjusted hazard ratio [HR] = 1.022 for 28-day mortality; HRadj = 1.031 for in-hospital mortality) and RDW (HRadj = 1.085 for 28-day mortality; HRadj = 1.094 for in-hospital mortality) were found to predict mortality (all P < 

SUBMITTER: Ding S 

PROVIDER: S-EPMC12758782 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature