Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner.

ABSTRACT: Alcohol use disorder (AUD) is highly prevalent and associated with substantial morbidity and mortality. While there are currently three FDA-approved medications for AUD, none specifically target the withdrawal/negative affect stage of AUD, underscoring the need to understand the underlying neurobiological adaptations associated with this critical stage of the addiction cycle. One key region involved in alcohol withdrawal and negative affect is the prelimbic cortex, a subregion of the medial prefrontal cortex. In the present study, we used male and female PV, SOM, and VIP reporter mice to examine cellular and synaptic adaptations in all three major classes of prelimbic cortex interneurons following 72-hour withdrawal from a continuous-access to two-bottle choice model of alcohol. We found t

SUBMITTER: Quadir SG 

PROVIDER: S-EPMC12758890 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature