Association of systemic inflammation with balance and falls in older adults: National Health and Nutrition Examination Survey and Mendelian randomization study.

ABSTRACT:

Background

Falls are a leading cause of morbidity in older adults, with emerging evidence suggesting that systemic inflammation may contribute to this risk. C-reactive protein (CRP), a biomarker of inflammation, has been linked to various health issues, including declines in physical function. However, its direct influence on balance and fall risk remains uncertain. This study investigates the association between CRP levels and balance using observational data and Mendelian randomization (MR) to explore its causal role in fall risk.

Methods

We analyzed data from the 2021-2023 National Health and Nutrition Examination Survey (NHANES), including 1215 participants aged 60 and older. CRP levels were measured using immunoturbidimetric assays, and balance was assessed via the Modi

SUBMITTER: Fakorede S 

PROVIDER: S-EPMC12758964 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature