Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.

ABSTRACT:

Background

The possible joint association of vitamin D and obesity in regard to clinical biomarker-based biological aging process has not been well studied. We investigated the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and body mass index (BMI) with phenotypic age (PhenoAge) and Klemera-Doubal method Biological Age (KDM-BA) acceleration.

Methods

This study was conducted using data from participants in the UK Biobank baseline survey. Restricted cubic splines and multivariable logistic regression analyses were used to investigate the associations of serum 25(OH)D concentrations and BMI with PhenoAge and KDM-BA acceleration. Mediation analyses were conducted to assess whether biological age acceleration potentially mediated the

SUBMITTER: Pan Z 

PROVIDER: S-EPMC12758972 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature