Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap.

ABSTRACT: Understanding the spatiotemporal dynamics of immune cells in living organisms is a major goal in bioimaging. Intravital microscopy enables direct observation of cellular behavior over time with tissue-to-subcellular resolution, making it essential for investigating immune responses across tissues, conditions, and disease contexts. However, most intravital microscopy data remain siloed in individual labs, limiting reuse, standardization, and large-scale analysis. To address these limitations, we present Immunemap, an open-data platform and interactive atlas of immune cell motility. Immunemap currently provides access to over 58,000 curated single-cell tracks and more than 1,049,000 cell-centroid annotations from 400 intravital microscopy videos in murine models, spanning diverse tissues and

SUBMITTER: Pizzagalli DU 

PROVIDER: S-EPMC12759063 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature