A Histone Code Functionally Linked to Replicative Senescence.

ABSTRACT: Cell states and biological processes are defined by their epigenetic profiles, distinctive composites of DNA- and histone-based chromatin components. However, the specific histone posttranslational modifications that distinguish cellular senescence and the impact of their distribution on transcription, especially with regard to gene length, have not been fully elucidated. Here, we show that promoter loss of symmetric dimethylated H4R3 (H4R3me^(2s)) and spreading of trimethylated H3K79 (H3K79me³) across gene bodies are functional features of replicative senescence associated with gene upregulation. We report that highly upregulated genes in replicative senescence exhibit enrichment of H3K79me³ and, in contrast to the characteristic trend of aging cells and ti

SUBMITTER: Suter T 

PROVIDER: S-EPMC12759110 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature