Regulating Promiscuous Catalysis via Substrate-Induced Transient Assembly.

ABSTRACT: In nature, substrate-induced assembly is a fundamental requirement for a wide range of enzyme-driven chemical transformations. Systems chemists have introduced synthetic substrate analogues that have proven effective in enhancing catalytic activities of assembling peptide folds, and mimic primitive enzymes. However, how catalytic promiscuity, the ability of one catalyst to catalyse multiple orthogonal reactions, might have shaped the diversification of prebiotic chemistry, remains largely unaddressed. Herein, we report a novel transient, substrate-induced co-assembly between a lysine-rich pre-assembling peptide and Fmoc-glycine. The nanostructure formed under nonequilibrium conditions provides the suitable microenvironment to promote the potential of catalytically active amino acids, perfo

SUBMITTER: Chatterjee A 

PROVIDER: S-EPMC12759214 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature