Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009-2018.

ABSTRACT:

Background

Longitudinal data are scarce on sepsis bundle adherence and associated survival at a country or regional level.

Methods

A population-based electronic health record database was leveraged to determine temporal trends in sepsis bundle adherence (empirical broad-spectrum antibiotic administration, blood culture collection, lactate measurement) on sepsis onset day and antimicrobial resistance (AMR) prevalence. This study included all adult hospitalizations for community-acquired sepsis at 41 publicly funded hospitals in Hong Kong between 2009 and 2018. Generalized estimating equations were used to assess the association between full bundle adherence and its individual elements with hospital mortality.

Results

Among 421 096 cases of community-acquired sepsis, th

SUBMITTER: Zhang JZ 

PROVIDER: S-EPMC12759782 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature