Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.

ABSTRACT: Metastasis of primary tumors leads to a very poor prognosis for patients suffering from cancer. Although it is well established that not every tumor will eventually metastasize, it is less clear whether primary tumors acquire genetic alterations in a stochastic process at a late stage, which make them invasive, or whether genetic alterations acquired early in the process of tumor development drive primary tumor growth and determine whether this tumor is going to be metastatic. To address this issue, we tested genes identified in a large-scale comparative genomic hybridization analysis of primary tumor for their ability to confer metastatic properties on a cancer cell. We identified amplification of the ACK1 gene in primary tumors, which correlates with poor prognosis. We further show that

SUBMITTER: van der Horst EH 

PROVIDER: S-EPMC1276100 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature