Hormonal Contraceptive Use, Stress Disorders, and Cardiovascular and Thrombotic Risk in Women.

ABSTRACT:

Importance

Stress and its psychiatric consequences-including depression, anxiety, and posttraumatic stress disorder (PTSD)-are pertinent to women's cardiovascular health, but research on intersections with relevant sex-specific factors (eg, hormonal contraceptives) is lacking.

Objective

To examine whether stress-related psychiatric diagnoses moderate associations between hormonal contraceptive use and cardiovascular and thrombotic risk.

Design, setting, and participants

This retrospective cohort study included electronic health record data collected from a US hospital-based biobank and analyzed from May 2, 2024, to November 3, 2025. Participants were women aged 18 to 55 years who consented into the biobank before or on September 12, 2020.

Exposures

Lifetime his

SUBMITTER: Thomas JL 

PROVIDER: S-EPMC12761333 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature