Infrapatellar Fat Pad Glucocorticoid Injection in Knee Osteoarthritis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Intra-articular glucocorticoid injections are widely used to alleviate knee osteoarthritis (OA) pain, but evidence suggests these injections may cause cartilage loss. The infrapatellar fat pad (IPFP) and synovium are important sources of inflammation in knee OA; injecting glucocorticoid into the IPFP may not only provide anti-inflammatory effects but also reduce cartilage deterioration in patients with inflammatory knee OA.

Objective

To evaluate the effect and safety of glucocorticoid injections into the IPFP in individuals with inflammatory knee OA.

Design, setting, and participants

This randomized, double-blind, placebo-controlled trial included patients aged 45 years and older with inflammatory knee OA at 4 centers in China. Patients were enrolled from A

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12761338 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature