Nephroprotective Potential of Olea europaea Leaf Extract Against Combined Noise and Toluene-Induced Oxidative and Histopathological Renal Injuries in Wistar Rats.

ABSTRACT: Noise and toluene are environmental stressors that induce oxidative stress and inflammation, contributing to renal dysfunction. This study evaluated the protective effects of Olea europaea leaf extract (OeLE; 40 mg/kg/day) against combined noise- and toluene-induced nephrotoxicity in Wistar rats. Forty-eight male rats were divided into eight groups and exposed for 6 weeks (6 h/day, 5 days/week) to noise, toluene, or their combination, with or without OeLE supplementation. Renal function biomarkers (urea and creatinine), oxidative stress indices (malondialdehyde, catalase [CAT], and superoxide dismutase [SOD]), histopathology, and in silico docking targeting key redox and inflammatory mediators (CAT, SOD, IL-1β, TNF-α, and NF-κB) were assessed. Co-exposure caused significant renal dysfuncti

SUBMITTER: Ben Attia T 

PROVIDER: S-EPMC12761346 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature