Manganese-Induced Production of Antioxidant Polyene Steroids in the Extremophile Fungus Talaromyces fuscoviridis Isolated From Copper-Mine Soil.

ABSTRACT: The fungus Talaromyces fuscoviridis was isolated from soil collected in a copper-mine tailings basin in Pará State, Brazil, an extreme environment that can induce the production of bioactive secondary metabolites. Extracts and fractions obtained after cultivation were analyzed by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and compared using Global Natural Products Social molecular networking (GNPS), which revealed a family of seven putative polyunsaturated steroids. Isolation led to the characterization of two major steroids: the known Ergosta-3(4),5(6),7(8),14(15),22(23)-pentaene (1a) and a previously unreported metabolite, Ergosta-5(6),7(8),14(15),22(23)-tetraen-3-ol (2a). Their structures were elucidated through comprehensive spectroscopic and spectrome

SUBMITTER: Alves MAPMDS 

PROVIDER: S-EPMC12761365 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature