Abelmoschus Manihot flowers inhibit dysbiotic Enterobacteriaceae expansion by promoting Clostridium bolteae-mediated hypoxia restoration.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is a chronic inflammatory disease that has become prevalent worldwide. Excessive expansion of Enterobacteriaceae is a key feature of dysbiosis in IBD patients, which further exacerbates intestinal inflammation. Therefore, inhibiting the dysbiotic expansion of Enterobacteriaceae is a promising strategy for the treatment of IBD. We investigated the effects of Abelmoschus manihot (A. manihot) flowers on the intestinal microbiota during colitis.

Results

We found that A. manihot flowers are capable of ameliorating murine colitis and suppressing Enterobacteriaceae expansion, not by direct action but rather by promoting the growth of Lachnospiraceae, particularly Clostridium bolteae. Bacterial depletion and recolonization confirmed that C

SUBMITTER: Li C 

PROVIDER: S-EPMC12763845 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature