Cinnamic acid improves insulin sensitivity in prediabetic mice through branched-chain amino acid metabolic reprogramming.

ABSTRACT:

Background

Insulin resistance is a key pathological feature in the early stages of type 2 diabetes mellitus (T2DM), often associated with obesity and metabolic dysfunction. Cinnamic acid (CA) is a natural compound found abundantly in cinnamon and other dietary sources, has demonstrated antidiabetic potential. However, its preventive role in improving insulin sensitivity during the prediabetic stage and the underlying mechanisms remain poorly understood.

Methods

This study evaluated the preventive effects of cinnamic acid in a high-fat diet (HFD)-induced prediabetic mouse model. Male C57BL/6 N mice were divided into control and intervention groups and treated with CA for 12 weeks. Glucose and insulin tolerance tests, histopathological analysis, serum biochemistry, transcripto

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12763852 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature