Age-multiplied low density lipoprotein cholesterol (LDL-C) burden (AM-LDL) index stratifies bleeding and ischemic risk in acute coronary syndrome: implications for early therapeutic intensification.

ABSTRACT:

Background

Early identification of high-risk individuals after Acute Coronary Syndrome (ACS) is critical for tailoring intensive lipid-lowering therapy, a cornerstone of secondary prevention to alleviate the growing global burden of cardiovascular diseases, while practical tools integrating lipid burden and vascular aging remain lacking. This study proposes the age-multiplied low density lipoprotein cholesterol (LDL-C) burden (AM-LDL) index to quantify cumulative atherogenic exposure and stratify 1-year ischemic and bleeding risk.

Methods

This post-hoc analysis utilized data from the prospective "Beijing Risk Intervention Clinical (BRIC) Study", which enrolled post-percutaneous coronary intervention (PCI) ACS patients from a 30-center Chinese cohort and followed them for one

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12763911 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature