Microgravity activates monocyte ERK1/2 signaling and modulates the response to lipopolysaccharide.

ABSTRACT:

Background

Microgravity alters immune cell function, potentially compromising host defense during spaceflight. Because appropriate immune regulation is also critical in chronic inflammatory and autoimmune conditions, insights from spaceflight biology may have broader implications for human health. Monocyte activation via the p44/42 MAPK pathway is central to inflammatory responses, yet the influence of microgravity on this signaling cascade remains incompletely understood. This study aimed to determine how microgravity affects basal and lipopolysaccharide (LPS)-stimulated ERK1/2 kinases (also known as p44/42 MAP kinases) activity in human monocytes, focusing on signaling state redistribution at both single-cell and population levels.

Methods

Monocytes were cultured during sp

SUBMITTER: Mammadov RA 

PROVIDER: S-EPMC12763956 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature