MiR-18a-5p serves as a risk factor in perioperative respiratory adverse events in children under general anesthesia.

ABSTRACT:

Purpose

Perioperative respiratory adverse events (PRAEs) are frequently encountered complications in pediatric anesthesia. The purpose of this experiment is to explore the significant role of miR-18a-5p in PRAEs, thereby providing a novel biomarker for PRAE clinical management.

Methods

Clinical data from 174 children undergoing general anesthesia were analyzed. MiR-18a-5p expression in serum and cells was analyzed via real-time quantitative PCR (qRT-PCR). Its diagnostic value for PRAEs was evaluated through receiver operating characteristic (ROC) curves, while logistic regression was selected to assess independent risk factors for PRAEs. In vitro experiments were conducted to determine miR-18a-5p effects on AEC-II cells proliferation, apoptosis, and lipopolysaccharide (LPS)-

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12763970 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature