Multienzymatic nanocatalysts attenuate acute pancreatitis via dual modulation of pyroptotic pathways and autodigestion blockade.

ABSTRACT: Acute pancreatitis (AP) is associated with a high mortality rate, and thereby its therapy is still a challenge. At the molecular level, single-cell RNA sequencing (scRNA-seq) analysis revealed a marked upregulation of pyroptosis (a recently characterized inflammatory programmed cell death pathway) and its key molecular complexes during AP, highlighting the pivotal role of pyroptosis in AP progression. Concurrently, the excessive activation of digestive enzymes within acinar cells triggers pancreatic tissue autodigestion, which exerts profoundly deleterious effects. Thus, in response to these AP pathological characteristics, this study designed a multi-enzyme catalytic system to attenuate pancreatic acinar cell pyroptosis, inactivate pancreatic enzymes, and suppress excessive inflammatory i

SUBMITTER: Dong X 

PROVIDER: S-EPMC12763986 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature