Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort.

ABSTRACT:

Background

Lead is a well-known neurotoxicant with no identified safe level. Prior studies found that childhood lead exposure is associated with decreased intelligence quotient (IQ) scores. However, most studies rely on a limited number of blood lead measurements. In this prospective pregnancy and birth cohort, we estimated cumulative childhood lead exposure using repeated blood lead concentrations and regression calibration, allowing for more accurate assessment of lead burden over time and its association with IQ.

Methods

This prospective study included 262 mother-child dyads from Greater Cincinnati enrolled in the Health Outcomes and Measures of the Environment (HOME) Study from 2003 to 2006. We obtained serial blood lead measurements and estimated cumulative childhood le

SUBMITTER: Vester A 

PROVIDER: S-EPMC12764035 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature