Identification and validation of shared key genes between Parkinson's disease and erectile dysfunction: a bioinformatics approach.

ABSTRACT:

Background

Erectile dysfunction (ED) and Parkinson's disease (PD) are prevalent conditions that considerably impair patients' quality of life. Emerging evidence suggests a potential relationship between ED and PD, possibly mediated by shared biological mechanisms. This research seeks to examine shared transcriptomic alterations and the underlying biological pathways associated with ED and PD.

Methods

Gene expression profiles related to ED and PD were derived from the Gene Expression Omnibus database, specifically the GSE2457 and GSE7621 datasets. Differentially expressed genes (DEGs) between patients and controls were identified through differential expression analysis. Functional enrichment analyses, including Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene

SUBMITTER: Fan Y 

PROVIDER: S-EPMC12764067 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature