Global burden, spatiotemporal disparities, and sex-specific trends of early- and late-onset Alzheimer's disease and other dementias: a comparative analysis and projections to 2035.

ABSTRACT:

Introduction

Early-onset Alzheimer's disease and other dementias (EOAD) and late-onset Alzheimer's disease and other dementias (LOAD) represent significant global disease burden challenges. However, previous studies have frequently overlooked differences in their spatial distribution, population characteristics, temporal trends, and healthcare demands. This study aims to systematically compare the burden of EOAD and LOAD at global and regional levels from 1990 to 2021, analyzing disparities in spatial patterns, demographic features, and temporal trajectories, while projecting future trends.

Methods

Data were extracted from the GBD 2021 database. EOAD was defined as age-standardized cases among individuals aged 40-64 years, and LOAD as those aged ≥ 65 years. Primary outcomes

SUBMITTER: Wu M 

PROVIDER: S-EPMC12764068 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature