Neurological complications associated with rapid weight loss and nutritional deficiencies following GLP-1 agonist use: a case report.

ABSTRACT: GLP-1 agonists have been a welcome addition to the armamentarium in the treatment of diabetes and obesity. While this class of medications is generally considered safe and effective, potentially severe neurological complications may be associated with rapid weight loss and nutritional deficiencies following GLP-1 agonist use. We present a 37-year-old woman who was prescribed semaglutide for diabetes and weight loss who subsequently experienced significant weight reduction and rapid glycemic control over three months. Thereafter, she developed progressive right leg numbness and weakness, followed by similar symptoms in the left leg, and blurred vision. Initially diagnosed with B12 deficiency, her symptoms worsened despite supplementation, leading to acute encephalopathy and transfer to a te

SUBMITTER: Zahir A 

PROVIDER: S-EPMC12764084 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature