Effect of dexmedetomidine on postoperative mortality and prognosis: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

This meta-analysis aimed to systematically evaluate the impact of intraoperative dexmedetomidine (DEX) on postoperative mortality and clinical outcomes in surgical patients, addressing existing controversies in the literature.

Methods

We conducted a systematic review of randomized controlled trials (RCTs) from PubMed, Embase and Cochrane Library (inception to October 8, 2024; PROSPERO: CRD42024583524). Included studies compared intraoperative DEX against controls (placebo/active comparators) in adults undergoing general anesthesia. Primary outcome was mortality; secondary outcomes included postoperative delirium (POD), ICU/hospital stay, mechanical ventilation duration, and safety endpoints. Risk ratios (RR) or mean differences (MD) with 95% confidence intervals (C

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12764088 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature