Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics.

ABSTRACT:

Background

Intervertebral disc degeneration (IDD), characterized by multifaceted pathological mechanisms, presents substantial therapeutic challenges. Globally, over 50% of individuals experience IDD-related low back pain (LBP), a debilitating condition associated with high recurrence rates and profound socioeconomic burdens. Current clinical strategies demonstrate limited efficacy in halting IDD progression, underscoring the critical need for targeted therapies.

Methods

We analyzed the gene expression data of IDD mRNA and miRNA in the GEO database. Subsequently, the mRNA was screened for differentially expressed genes (DEGs) using R language. Immediately after that, we conducted a screening analysis of DEGs on miRNAs, and then used Venn diagrams to obtain hub genes by takin

SUBMITTER: Yan J 

PROVIDER: S-EPMC12764095 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature