Distinct body fat distribution and its association with metabolic syndrome in Tibetan population.

ABSTRACT:

Objective

To characterize the specific pattern of body fat distribution and its association with metabolic syndrome (MetS) among Tibetan adults, an understudied population with distinct high-altitude adaptations, and to identify potential mediating biomarkers in serum lipoprotein profiles.

Methods

A total of 1480 participants from the Tibetan cohort and the NHANES were included. Principal component analysis and Mantel tests were employed to identify Tibetan-specific body fat indicators. Linear models assessed associations with metabolic syndrome (MetS), and mediation analyses evaluated the indirect effects of serum lipoproteins.

Results

Tibetans showed distinct trunk and total fat mass compared to other ethnic/racial groups. Trunk fat percentage was identified as a ri

SUBMITTER: Yuan L 

PROVIDER: S-EPMC12764113 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature