Identification of immunomodulating properties of postbiotics from lactobacilli using the zebrafish (Danio rerio) model.

ABSTRACT:

Background & objectives

Probiotics are increasingly used in the pet industry to enhance the health and well-being of companion animals. Among them, Lactobacillus strains and their metabolites have demonstrated the ability to maintain immune homeostasis, modulate immune responses, and exhibit antiviral properties. Despite growing interest in postbiotics, non-viable microbial products or metabolic byproducts, scientific literature on their effects remains limited. This study investigates the immunomodulatory and antiviral properties of three postbiotics derived from heat-inactivated Lactobacillus strains using an adult zebrafish (Danio rerio) model challenged with viral hemorrhagic septicemia virus (VHSV).

Methods

A total of 330 zebrafish were assigned to five groups: a non-ch

SUBMITTER: Nikapitiya C 

PROVIDER: S-EPMC12764115 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature