Impact of Anatomically Defined Retinal Zones on Ultrawide-Field Fluorescein Angiography Nonperfusion Measurements in Diabetic Retinopathy.

ABSTRACT:

Introduction

The aims of the study were to determine the effect of retinal zone placement on nonperfusion index (NPI) measurements using ultrawide-field fluorescein angiography (FA) in eyes with diabetic retinopathy (DR) and assess its association with disease progression.

Methods

The study analyzed retinal periphery zones based on FA findings in 18 eyes without DR to standardize anatomical boundaries. NPI measurements were then conducted on a separate set of 285 eyes with DR. Eyes were grouped by NPI levels, and Cox regression was used to examine the association between nonperfusion in the mid-peripheral and far peripheral retina and progression to proliferative diabetic retinopathy (PDR).

Results

The retinal zones defined by FA (FA-defined zones) were similar in siz

SUBMITTER: Ashraf M 

PROVIDER: S-EPMC12764354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature