Glucagon-Like Peptide-1 Receptor Agonist Use Does Not Impact Spine Surgery Outcomes: A Systematic Review and Meta-Analysis.

ABSTRACT: Study DesignSystematic Review and Meta-Analysis.ObjectivesDespite a surge in the use of Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in spine surgery candidates, evidence on their perioperative use remains unclear. This meta-analysis aimed to synthesize the evidence on the safety and efficacy of GLP-1 RA use in patients undergoing spine surgeries.MethodsA systematic search of PubMed (MEDLINE), Embase, Scopus, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted. Studies that compared spine surgery outcomes in GLP-1 RA users and non-users were included. Two reviewers independently selected articles. (PROSPERO: CRD420251061447).ResultsEleven retrospective studies reporting on 27,143 patients were included. Three studies focused on the ce

SUBMITTER: Ibrahim S 

PROVIDER: S-EPMC12764418 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature