Acquisition of ampliconic sequences marks a selfish mouse t-haplotype.

ABSTRACT: Mendelian genetics posits equal transmission of alleles, but selfish alleles can bias the transmission of large genomic regions or entire chromosomes. One long-standing question is how transmission bias evolves to encompass large genomic regions. Mus musculus (house mouse) t-haplotypes exhibit up to 99% transmission bias from heterozygous males and harbor selfish alleles genetically linked to large inversions spanning the proximal half of chromosome 17. Here, by generating a high-quality, single-haplotype assembly of a t-haplotype, we reveal the evolution of eight large amplicons with known and candidate selfish alleles as a distinct genetic feature. Three amplicons are conserved in closely related Mus species, and two have known selfish alleles in the oldest inversion, implicating amplico

SUBMITTER: Swanepoel CM 

PROVIDER: S-EPMC12764527 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature